Postgraduate Research Assistant
Postdoctoral Research Associate
Grade 7 - £32,277 - £37,394, (Fixed Term 18 months), Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University
We are seeking to appoint a highly motivated Postdoctoral Research Associate (PDRA) to join a national consortium of investigators to work on a project entitled ‘Modified plant saponins for the control of liver fluke in livestock’. The project aims to optimise the anti-parasitic effects of saponins derived from non-food plants in controlling fascioliasis (caused by Fasciola hepatica liver flukes), an infection in over 30% of cattle and sheep in Europe where resistance to existing treatments is reported.
Saponins are present in common ivy (Hedera helix) at very high levels, are based on a single major triterpene core and can be very simply modified to single molecular species with proven biological activity against molluscs, nematodes and protozoan parasites. The efficiency of simple saponin extracts from a range of plant sources (including the national ivy bank) and modified saponins on a range of F. hepatica functions will be examined using advanced robotic instrumentation. Lead molecules identified in this manner will be formulated for in vivo application and evaluated. The project will integrate the supply of raw material from a non-food plant on a multi-tonne scale, the isolation, modification and formulation of chemicals present in large quantities, optimisation of efficacy in controlling a major economic and animal welfare problem in sheep and cattle, and the development of a clear route to market.
Closing Date: Noon, 9 June 2015
Interview Date: 16 June 2015
For information and application forms please go to http://www.aber.ac.uk/en/hr/jobs/vacancies-external/
Completed Application Forms should be signed and returned to the Human Resources Recruitment Team by e-mail, or post. Email address: email@example.com / Tel: 01970 621927. NOTE: Please put the post reference on the front of your envelope and on your application form.
Postdoctoral Fellow - Parasite Genomics
Postdoctoral Fellow - Parasite Genomics
Salary range: £30202 to £37860 per annum plus excellent benefits.
We are seeking to recruit an enthusiastic and ambitious Postdoctoral Fellow to play a leading role in a large, collaborative project using genomic approaches to understand the genetics of anthelminthic drug resistance in Haemonchus contortus and Teladorsagia circumcincta, the most important gastrointestinal nematode parasites of small ruminants. The post is funded by BBSRC, and will be for 3 years in the first instance, with the possibility of extension for an additional 2 years. Key aspects of the role are the analysis and interpretation of whole genome resequencing data from a genetic cross, of populations of worms from UK farms, and of individual worms from the same populations. The role will also include working with colleagues to produce a reference genome for T. circumcincta.
The project aims to leverage the understanding of anthelminthic resistance we gain to develop practical guidance for on-farm management, and so will involve collaboration with vets, parasitologists, modelers and economists (https://bugconsortium.wordpress.com). Strong candidates will need excellent communication and organizational skills, as explaining the results of genomic analyses to these professionals in an accurate but accessible way will be critical. The post will be based with the parasite genomics group, a diverse and collaborative research environment, and the institute has unparalleled resources and expertise available to support genomic research.
This post is fixed-term for 3 years in the first instance, possible extension to 5 years.
Closing date for applications is: 29th March 2015.
Please see http://tinyurl.com/q3v8wzw for further details and to apply.
Informal enquiries can be made to James Cotton (firstname.lastname@example.org)